Abstract:In the process of in-situ leaching for uranium extraction, not only do uranium minerals dissolve along the leach solution flow path, but significant dissolution of other minerals also occurs, with the quantity of mineral dissolution and precipitation increasing spatially along the leach solution flow direction. This study focused on the pumping unit located in the southern region of the C12 mining area within the Bayan-Ula Uranium Mine, employing an inverse simulation method to investigate the spatial distribution characteristics and patterns of mineral dissolution and precipitation along the leach solution transport pathway. The research findings indicate that during the acid leaching process for uranium extraction, when the leachate runoff reaches 27.10 m, the main minerals dissolved include anorthite (16.95 g.L-1^), albite (2.8 g.L-1^{), potassium feldspar (2.00} g.L-1^{), hematite (8.74 m}g.L-1^{), and pyrite (7.72 m}g.L^-1). Minerals prone to precipitation predominantly comprise gypsum (10.8 mg.L-1^{) and pyrite (7.72 m}g.L^-1). Furthermore, minerals undergoing both dissolution and precipitation involve gypsum (10.45 g.L^-1 of precipitation), while the newly formed minerals primarily consist of illite (13.65 g.L-1^{) and kaolinite (3.90} g.L^-1).The spatial evolution pattern of mineral dissolution and precipitation demonstrates a consistent increase along the leach solution flow path, highlighting the claying alteration of feldspars and the precipitation of gypsum as crucial mechanisms contributing to the blockage of the ore-bearing layer in acid leach uranium mining.