Abstract:In order to explore the production changes of uranium ore in low-permeability sandstone under different factors, a numerical model of effective stress-seepage was established according to the relationship between the effective stress and seepage characteristics of the reservoir. The daily water production was used to analyze the production variation of the reservoir under fluid-structure interaction, and the effects of injection pressure, initial permeability and well spacing on production were analyzed by combining the coefficient of variation method. The results show that the reservoir production will enter the stable state faster and the production will be higher under the consideration of fluid-structure interaction, and the greater the stress sensitivity coefficient, the more obvious the effect of the reduction of effective stress on the formation permeability. The greater the injection pressure, the greater the decrease in the area of the formation effective stress, and the increase in the area of formation permeability increases, resulting in a gradual increase in production. Under the consideration of fluid-structure interaction, the yield increases with the increase of initial permeability and the growth rate is faster. Under the consideration of fluid-structure interaction, with the increase of well spacing, the effect of decreasing effective stress between injection-production wells is weakened, and the increasing trend of permeability between injection-production wells is also decreased, resulting in a gradual decrease in production.Combined with the changes of the coefficient of variation of various factors, it can be obtained that the injection pressure has a more obvious effect on the yield effect. This study will help to establish a complete uranium production scheme for uranium in-situ leaching in low-permeability sandstone uranium mines.